Ensartinib is currently undergoing phase II and III clinical trials for the treatment of NSCLC [4]; preclinical investigations have shown that it is more active than the approved ALK inhibitors crizotinib, alectinib, and ceritinib and that it retains activity even in models with ALK mutations that confer resistance to these agents [5]. The gene discussed is ALK; the disease is non-small cell lung carcinoma.