Correlates with shorter survival in osteosarcoma [87]Therapeutic option for the combination treatment of RMS [88]Potential target for immunotherapy [87,89,105]Impairs terminal differentiation [86]Increases the invasive and migratory capabilities of glioma cells by facilitating interactions with extracellular matrix proteins [86]Facilitates angiogenesis by sequestering angiostatin [86]Increases tumor growth [86]Potential therapeutic target for treating childhood CNS cancers [86,89]. The gene discussed is PLG; the disease is central nervous system cancer.