Likewise, PEG10, an RNA splice factor that is crucial for placental and embryonic development [24], is reported to play a role in the progression of several types of human cancers, including leukemia, breast cancer, prostate cancer and hepatocellular carcinoma [25,26,27], and has been proposed as a therapeutic target for prostate cancer [26,27,28]. Here, PEG10 is linked to Familial prostate cancer.