FOXP3 and endometriosis: Tanaka et al. [36] found a significantly decreased CD45RA-/Foxp3high activated (suppressive) Treg number in the eutopic endometrium and endometrioma samples of the affected women which were in accordance with our recent data Albeit elevated TIM-3 receptor expression identifies a Treg subset highly effective in inhibiting pathological Th1 and Th17-biased immune response [54], we suppose, that the observed decrease in peripheral and peritoneal Treg numbers and the decreased FoxP3 expression may mark diminished regulatory function in endometriosis.