Obesity has been suggested to promote oxidative stress, as obesity promotes the infiltration and activation of macrophages and monocytes into adipose tissue [17] which in turn release elevated levels of pro-inflammatory adipokines, such as tumor necrosis factor alpha (TNF-a) and interleukin-6 (IL-6) [17,18]. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.