Several studies have been published in this regard, showing that the number of CD14+ and CD16+ EVs is inversely associated with the severity of NAFLD-related liver fibrosis, while also increasing the diagnostic capability of the enhanced liver fibrosis score (LFS) in patients with NAFLD (AUC: 0.948 and 0.967 for CD14+ and CD16+ EVs, respectively, vs. 0.915 for LFS alone) [79]). Here, CD14 is linked to metabolic dysfunction-associated steatotic liver disease.