Intriguingly, we also found YAP nuclear accumulation in cells with nesprin-1 mutation responsible for a congenital myopathy and associated with defects in nuclear morphology [9,19], but not in cells carrying the LMNAH222P mutation responsible for a less severe form of the disease and much milder nuclear envelope structural defects. This evidence concerns the gene SYNE1 and congenital myopathy with cores.