CDK5 and Alzheimer disease: Additionally, it was shown that DRP1 can be trans-S-nitrosylated by cyclin-dependent kinase 5 (CDK5) in AD models [102], and that an increase in S-nitrosylated DRP1 induced by decreased S-nitrosoglutathione reductase (GSNOR) expression can occur in primary cells undergoing senescence [103].