Dactolisib also suppressed 4E-BP1 phosphorylation at Thr37/46 and Ser65 in Gr-MDSCs and PCa cells (Figure 4A,B), yet 4E-BP1 phosphorylation in T cells was largely resistant to Dactolisib treatment. Here, EIF4EBP1 is linked to posterior cortical atrophy.