The changes caused by the two inhibitors on PCa cells, T cells and Gr-MDSCs highlight the specificity of Dactolisib and Dasatinib: the dual PI3K/mTOR inhibitor Dactolisib dampened phospho-S6 and phospho-4E-BP1, whereas the TKi Dasatinib attenuated phospho-Src and phospho-p38 MAPK. This evidence concerns the gene EIF4EBP1 and posterior cortical atrophy.