Finally, mucosal profiling of pediatric-onset IBD further revealed two CD68+CD14+CD64hi Mɸ subsets with S100A8+IL-1β+TNFα+/− cells sharing their gene signature (TREM1/S100A9/S100A8/SLC11A1/CD300E/FPR1/VCAN) [46] with inflammatory CD14+CD163− MNPs in adult IBD [31]. The gene discussed is VCAN; the disease is inflammatory bowel disease.