In a choline deficient-high fat diet (CD-HFD) mouse model of NASH, activation of CD8+ T cells and NKT cells induced FFA uptake by hepatocytes via the lymphotoxin-β receptor and accelerated NASH to HCC transition by activating nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling in hepatocytes [68]. Here, CD8A is linked to metabolic dysfunction-associated steatohepatitis.