The C1 domain also recognizes tumor promotor phorbol esters, which induce non-lamellar phases but in a different manner to that caused by DAG or PE, such that PKC was associated with conditions related to cell growth, as in cancer [62,63], AD [64], CVDs [65], and immunological diseases [66], etc. Thus, not only do PKC–membrane interactions define relevant signaling events, but they also may be involved in pathophysiological and therapeutic processes [8,14]. Here, PRRT2 is linked to Alzheimer disease.