Our results suggested that marker(s) for hyperglycemic related breast cancer should be: 1) reduction in PI3P and PIP3 with increased PI4P and PI(3,4)P2 in HR+; 2) reduction in PI3P and PI4P with increased PIP3 in HER2+; and 3) increased PIP3 with decreased PI3P in TNBC. Here, ERBB2 is linked to breast carcinoma.