AKT1 and breast cancer: While PI3K/Akt signaling is one critical nexus between T2D and breast cancer that has been shown to play an important role in glucose metabolism through glycolysis mediated via cytoskeletal remodeling [44], assessing the changes in the accumulation of 4′- and 5′-phosphorylation in response to changing serum glucose concentrations has illustrated a potential breast cancer specific role for their related kinases and phosphatases.