These alterations in MuRF-1 and MAFbx/atrogin-1, however, seem to take place even before the presence of weight loss [70] or in early stages of cancer cachexia [71], whilst patients with cancer cachexia have been shown to present an inverse relation between the muscle expression of ubiquitin mRNA and the level of weight loss [72]. This evidence concerns the gene TRIM63 and Cachexia.