PRDM16 and obesity due to melanocortin 4 receptor deficiency: The most likely explanation for enhanced beige adipocytes in scWAT is trans-differentiation of WAT, as illustrated by the marked downregulation of C/EBPα and C/EBPβ and upregulation of PRDM16 [69,70] and PPAR-γ [71], thereby overcoming the negative effects of obesity [72].