Obesity thus caused a diabetic-like state that, in scWAT, was characterized with a greater abundance of biomarkers for adipocyte differentiation (i.e., C/EBP-α, C/EBP-β, and PPAR-γ), fatty acid transport and oxidation together with a downregulation of markers of energy sensing (i.e., AMPK/SIRT1/PGC-1α) and UCP1, that were reversed with exercise. The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.