Consistent with the mRNA and protein levels of CXCL2, IL-17A in the murine COPD model (Figure 4 and Figure 5), treatment with GG plus AR, GA, and TN in LA4 cells and HMC-1 cells inhibited the expression of CXCL2 and IL-17A, the cytokines that recruit neutrophils to inflammatory tissues, without causing any toxicity (as determined by MTT assay, data not shown) (Figure 8A,B), whereas CXCL2 and IL-17A levels in LA-4 cells were not decreased by the treatment with GA (low dosage) compared with the CFA control. This evidence concerns the gene CXCL2 and chronic obstructive pulmonary disease.