One recent study showed that alcohol drinking in the triple-transgenic model of AD (3xTg-AD) mice induced deficits in cognitive and emotional functions compared to wild-type controls, and induced pathological changes such as the hyperphosphorylation of Tau-Ser199/202 in neuronal cell bodies and the dorsal hippocampus (CA1) in 3xTg-AD mice 1 month post alcohol drinking [35]. Here, MAPT is linked to Alzheimer disease.