The effects of hepatic steatosis on hepatic SIRT1, sterol regulatory element binding transcription factor 1 (SREBP-1c), peroxisome proliferator-activated receptor γ coactivator-1 alpha (PGC-1α), oxidation and antioxidation activities in the liver are shown in Figure 3. The gene discussed is SIRT1; the disease is Hepatic steatosis.