The mRNA levels of the pro-apoptotic marker B-cell lymphoma 2-associated X protein (Bax) were significantly increased by CyCl treatment, whereas the mRNA levels of anti-apoptotic markers B-cell lymphoma 2 (Bcl2) cellular inhibitor of apoptosis protein (cIAP)-1, and cIAP2 were significantly decreased in CyCl-treated colon cancer cells (Figure 3B and Figure S1B). Here, BAX is linked to malignant colon neoplasm.