HI abolished the acute-insulin-induced increase in GLUT4 plasma membrane levels, indicating insulin resistance (Figure 6A,B), and this response was restored in the presence of RSV (HI: 100%, HI+I: 92% ± 6.0 %, RSV+HI+I: 160% ± 11% of HI, p < 0.01; Figure 6A). The gene discussed is SLC2A4; the disease is Insulin resistance.