COL4A1 and neoplasm: Furthermore, the evaluation of co-expressing genes across these cohorts of patients revealed a higher and significant correlation of CDH5 with additional endothelial-related genes like CD34, TIE1, FLT4, KDR and COL4A1 (Figure 6b and Figure S4), confirming the strong association of endothelial-related signature in this neoplasia.