Among these proteases, studies on ADAMTS1, first member of the ADAMTS (A Disintegrin And Metalloprotease with ThromboSpondin motifs) family [4], underlined its tumor suppressive [5,6] but also its protumorigenic properties [7,8,9], including its key contribution for the acquisition of an endothelial-like (EL) phenotype [10] or its competences to modulate the immune response [11]. This evidence concerns the gene ADAMTS1 and neoplasm.