IMD1-53 mediates a variety of biological effects such as inhibits cell proliferation, migration and apoptosis and protects against myocardial injury, abdominal aortic aneurysm, and vascular calcification by activating PI3K/Akt, AMPK or cAMP/PKA [7, 42, 43]. The gene discussed is AKT1; the disease is abdominal aortic aneurysm.