NR3C2 and kidney disorder: It is well known that activation of the aldosterone/MR pathway, in the presence of a liberal sodium (1.6% Na+), diet, is a risk factor for a variety of cardiovascular/renal diseases and that MR antagonists (MRA) can ameliorate these adverse effects (Takeda et al. 2000, Martinez et al. 2002, Rocha et al. 2002, Endemann et al. 2004, Jain et al. 2009).