TMEM175 and Parkinson disease: TMEM175 is implicated in cellular proteostasis and its mutation is associated with the development of Parkinson’s disease through a yet unknown mechanism, underscoring the importance of this channel to regulation of cellular homeostasis (Blauwendraat et al., 2019; Cang et al., 2015; Iwaki et al., 2019; Jinn et al., 2019; Jinn et al., 2017; Krohn et al., 2020; Nalls et al., 2014).