TMEM175 and Parkinson disease: Due to hTMEM175’s association with lysosomal homeostasis and the development of Parkinson’s Disease (Blauwendraat et al., 2019; Cang et al., 2015; Iwaki et al., 2019; Jinn et al., 2019; Jinn et al., 2017; Nalls et al., 2014), future studies will be necessary to identify stimuli that regulate gating and to understand how these stimuli alter the equilibrium between open and closed states to regulate lysosomal K+ flux.