MKRN3 and central precocious puberty: To date, MKRN3 mutations have been described in 58 patients with CPP from 35 different families [2, 6, 12, 20–24]; these include 23 different loss-of-function and 11 missense mutations of MKRN3 and represent the most frequent genetic cause of CPP since being identified in 2013 [10].