In accord, vGluT1 signal was considerably ~ 283 ± 87% higher in early PD (n = 5, P = 0.007, ttest) and 67.4 ± 32.8% lower in advanced PD (n = 5, P = 0.05, ttest) compared with control brains (n = 7; Fig. 6a,b and supplementary Fig. S3). This evidence concerns the gene SLC17A7 and Parkinson disease.