Contrary to miR-194-5p, E2F3 overexpression promoted cell cycle progression and EdU incorporation (Additional file 5: Fig. S5d-e), and hindered attenuation of pATM and γH2A.X (Fig. 4h) and reduction of DNA damage (Additional file 5: Fig. S5f) in irradiated pancreatic cancer cells. The gene discussed is E2F3; the disease is familial pancreatic carcinoma.