We have identified the molecular features of spinal cord astrocytomas in a relatively large cohort of this extremely rare tumor, revealing that spinal cord astrocytomas were mainly wildtype for IDH1, that the MGMT promoter methylation rate was low, that the BRAF V600E mutation was associated with a good prognosis, and that the TERT promoter mutation was associated with a poor prognosis. The gene discussed is MGMT; the disease is neoplasm.