Both overall obesity and intra-abdominal fat volume have been associated with similar findings of elevated serum leptin, insulin and inflammatory cytokine concentration, insulin resistance and cardiovascular dysfunction, which may be ascribed to the fact that both total body fat percentage and visceral fat volume appear directly related [2, 6, 7, 24, 25]. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.