Additionally, a module identified only in females suggested female EBR may be characterized by downregulation of immune and defense responses, which may involve impairment of coagulation, IL6-JAK-STAT3 signaling, and interferon gamma (IFNγ) response, with IFNγ particularly implicated as a key player involved in PTSD-like response to stress in females. The gene discussed is STAT3; the disease is post-traumatic stress disorder.