Next, to investigate the role of APC-KRASG12D-derived exosomes in the formation of NETs, the exosomes isolated from APC-WT and APC-KRASG12D mice were injected into APC-WT and APC-KRASG12D mice, and then whether the exogenously administered exosomes could be enriched in colon tissue and internalized by tumor cells was assessed. Here, APC is linked to neoplasm.