Three of the candidates, namely MET, TSC2, and RB1, that were affected by somatic mutations in TCGA patient cohort are genes found to be frequently mutated in ccRCC, either in literature [67–69] or in own data analyses (unpublished data), and were therefore selected for deep sequencing in patient cohort 1. This evidence concerns the gene TSC2 and nonpapillary renal cell carcinoma.