The distribution of RAB39B (RNA and protein) in cortical and midbrain regions could potentially explain the wide spectrum of clinical features that have been observed in individuals with mutations in RAB39B. Specifically, the function(s) of RAB39B in cortical and hippocampal regions are likely to be associated with the development of cognitive impairment, whilst its function(s) in the SNpc could be linked to the development of parkinsonism. This evidence concerns the gene RAB39B and Parkinsonism.