In our study, FN1 was identified as a hub gene interacting with ITGB3 and ITGA5 in the PPI network, which is consistent with the study of Bi et all [43]., who found that FN1 was a common hub gene in different stages (T1–T4) and grades (G1–G3) of BC. The gene discussed is ITGB3; the disease is breast cancer.