PVT1 is frequently involved in translocations occurring in multiple myeloma (MM) and murine plasmacytoma, where the t(6;15) (igκ-pvt1) and the t(15;16) (pvt1–igλ) fusion genes [88, 89] have been reported to upregulate PVT1 expression [90]. This evidence concerns the gene PVT1 and AL amyloidosis.