Downregulation of circPVT1 in B- and T-ALL models had no effect on PVT1 (as also observed in gastric cancer) [20], while causing a significant reduction in the proliferation rate and induction of apoptosis, associated with a decrease of MYC and BCL2 protein expression [50] (Fig. 3). This evidence concerns the gene MYC and acute lymphoblastic leukemia.