The first PVT1 alterations identified in lymphoma refer to Burkitt lymphoma (BL) cases carrying the t(2;8) or t(8;22) translocations (~ 20%), that juxtapose the IGL or IGΚ locus with the PVT1 gene, resulting in chimeric transcripts that contain PVT1 exons 1a or 1b spliced to the IG light chain constant region [54–56]. Here, PVT1 is linked to Burkitt lymphoma.