Evidence obtained across hematological malignancies indicates that the regulatory role exerted on cell proliferation by PVT1 (in AML, T-ALL, BL, MM) and circPVT1 (in T-ALL, B-ALL) is mediated by MYC, as also observed in a number of solid tumors [95, 96], and this regulation is active at post-transcriptional level (Fig. 3). Here, PVT1 is linked to acute myeloid leukemia.