For instance, target genes (FLAD1, SLFNL1, GNS, FBXL18, CYP2B7P) are commonly upregulated genes in metabolic-induced HCC and are associated with risk factors, such as diabetes, obesity, and other metabolic syndromes. The gene discussed is CYP2B7P; the disease is obesity due to melanocortin 4 receptor deficiency.