Taken together, among seven common obesity risk loci, the loci near TMEM18 (rs6548238), CDKAL1 (rs7754840), and FAIM2 (rs7138803) are associated with obesity, and loci near TMEM18 (rs6548238) and FAIM2 (rs7138803) are susceptibility loci for obese type 2 diabetes. The gene discussed is FAIM2; the disease is obesity due to melanocortin 4 receptor deficiency.