TMEM18 and obesity due to melanocortin 4 receptor deficiency: Taken together, among seven common obesity risk loci, the loci near TMEM18 (rs6548238), CDKAL1 (rs7754840), and FAIM2 (rs7138803) are associated with obesity, and loci near TMEM18 (rs6548238) and FAIM2 (rs7138803) are susceptibility loci for obese type 2 diabetes.