TMEM18 and obesity due to melanocortin 4 receptor deficiency: In addition, subjects with CC or CT genotypes of rs6548238 had elevated waist circumference, waist/hip ratio, BMI, fasting plasma glucose, HbA1c, TG, and TC, but declined HDL-C, suggesting that the locus near TMEM18 (rs6548238) may increase obesity/diabetes risk through inducing metabolic disorders.