TP53 and neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade: Although somatic TP53 mutations have been identified in various grades of PNETs as well as gastric, small bowel, colorectal, and appendiceal neuroendocrine tumors (NETs), there are no reported cases of NETs associated with a germline TP53 mutation [2, 5, 6].