PPI network and module analyses showed that 18 genes in the turquoise module (e.g., KIF18B, BUB1, BUB1B, KIF4A, and EXO1) and six genes in the pink module (e.g., KRT78, CNFN, SLURP1, PRSS27, and CRCT1) were associated with LOI in HNSCC. The gene discussed is BUB1B; the disease is head and neck squamous cell carcinoma.