Of these, the most impactful variant was a frameshift deletion in PALB2, which ClinGen has identified to be related to “familial ovarian cancer; hereditary nonpolyposis colon cancer; hereditary breast carcinoma; Fanconi anemia complementation group.” An additional 25 genes related to breast, ovarian, colon, and colorectal cancers are affected by missense variants. The gene discussed is PALB2; the disease is hereditary nonpolyposis colon cancer.