Recent clinical investigation reveals that COVID-19 mild patients had high level of IL1B, IFNγ, CXCL10/IP-10 and CCL2/MCP-1, while patients requiring ICU admission had higher level of GCSF, CXCL10/IP-10, CCL2/MCP-1 and CCL3/MIP-1A [4]. The gene discussed is IL1B; the disease is COVID-19.