Previously, some studies have identified a role of autophagy in AS progression, and FGF21 induces autophagy to protect against myocardial injury in ischaemia‐reperfusion25 and diabetic cardiomyopathy.26 However, whether autophagy is involved in FGF21‐inhibited AS remains largely unclear. Here, FGF21 is linked to diabetic cardiomyopathy.