Our data suggest that PINK1-dependent signalling may converge with LRRK2 signalling at Rab8A (Figure 3 and Supplementary Figure S8) and the antagonistic interplay between Ser111 phosphorylation and Thr72 phosphorylation is genetically concordant with how respective mutations in PINK1 and LRRK2 cause PD (Figure 6). The gene discussed is LRRK2; the disease is Parkinson disease.