PINK1 and Parkinson disease: Our data suggest that PINK1-dependent signalling may converge with LRRK2 signalling at Rab8A (Figure 3 and Supplementary Figure S8) and the antagonistic interplay between Ser111 phosphorylation and Thr72 phosphorylation is genetically concordant with how respective mutations in PINK1 and LRRK2 cause PD (Figure 6).