One of the mechanisms for the subsequent phosphorylation of STAT3 requires EGFRvIII to undergo nuclear translocation and form an EGFRvIII–STAT3 nuclear complex.19 However, the signaling circuitry of EGFR in GBM is highly complex and there are additional signaling axes that have been reported to result in STAT3 activation.8–12. Here, STAT3 is linked to glioblastoma.