APOE and early-onset autosomal dominant Alzheimer disease: After adjusting for age, sex, years of education and APOE-ε4 carrier status, PHS (status) showed a strong association in all three contrasts involving CN subjects (P ≤ 4.32e-06), while there was only a nominally significant effect between MCI and Alzheimer’s disease (P = 0.044; Table 2).