BIN1 and early-onset autosomal dominant Alzheimer disease: Moreover, recent works suggest that brain amyloid deposition is driven by the APOE locus (Yan et al., 2018) and that a genome-wide significant variant in the Alzheimer’s disease risk gene BIN1 (rs744373) is associated with tau pathology instead of amyloid pathology (Franzmeier et al., 2019).