Predictive performance over the model using APOE burden was improved by adding PHS when classifying CN versus MCI (AUC increase of 0.018) or by including PHS or PRS-cs when classifying CN versus MCI or Alzheimer’s disease (AUC increase of 0.011 or 0.02; Supplementary Table 2 and Fig. 2). This evidence concerns the gene APOE and Alzheimer disease.