TARDBP and Cognitive impairment: We therefore aimed to use BaseScopeTM to visualize C9orf72 RNA foci and hypothesized that the increased resolution, sensitivity and specificity that this technique confers would allow us to examine whether sense RNA foci are (i) associated with TDP-43 accumulation in extra-motor brain regions and (ii) independently associated with cognitive deficits in these extra-motor brain regions.