While the PI3K/AKT/mTOR pathway is extensively studied for its role in proliferative signaling in breast cancer, it is important to note that this central signaling axis also plays a critical role in regulating various aspects of metabolism including glycolysis[24,88], glutaminolysis[89], fatty acid (FA) synthesis[20,90], and FA oxidation (FAO)[24]. The gene discussed is PIK3CA; the disease is breast cancer.