F3 and venous thromboembolism: Microparticles, extracellular microvesicles (30–1,000 nm) detached from activated (monocytes, endothelial cells) or apoptotic cells and platelets (Figures 1, 2), harboring numerous cell surface receptors, mRNA, and biological activities, are dramatically increased in thrombosis-associated disorders, express coagulation activators like tissue factor and coagulation inhibitors, bear fibrinolytic properties, play a role in venous and arterial thrombosis and venous thromboembolism, and are emergent biomarkers in thrombotic diseases (Lacroix et al., 2013; Date et al., 2017).