F3 and venous thromboembolism: Tissue factor-microparticle disruption in inflammation seems to impact monocyte/macrophage-mediated endothelial activation (Date et al., 2017) and circulating tissue factor microparticles (Figures 1, 2); it also participates in venous thromboembolism and disseminated intravascular coagulation (van Es et al., 2015).