At the time pp71 was found to interact with Daxx, PML-NBs were a conundrum because, while the structures were eventually disrupted during productive infections with herpesviruses (Maul et al., 1993; Kelly et al., 1995) and adenoviruses (Korioth et al., 1995), viral genomes seemed to specifically localize to these structures (Ishov and Maul, 1996) and to initiate viral transcription adjacent to them (Ishov et al., 1997). This evidence concerns the gene DAXX and infection.