These experiments were some of the first to use RNA interference to study HCMV infection (Wiebusch et al., 2004; Wills et al., 2005) and provided the first definitive proof that a PML-NB protein (Daxx) was not pro-viral as had been proposed (Hofmann et al., 2002; Ishov et al., 2002), but was actually anti-viral. Here, DAXX is linked to cytomegalovirus infection.