Although pp71, like the oncoproteins of other DNA tumor viruses (Kalejta, 2004) inactivates the Rb tumor suppressors (Kalejta and Shenk, 2003a,b; Kalejta et al., 2003), there is no evidence that HCMV in general, or pp71 in particular, drives oncogenic cell division in virus-positive GBMs. This evidence concerns the gene RB1 and neoplasm.