PML and cytomegalovirus infection: These negative effects of Daxx on HCMV infections were quickly confirmed and extended to the additional PML-NB proteins (Figure 2) ATRX, BclAF1, PML, and Sp100 by multiple independent groups (Cantrell and Bresnahan, 2006; Everett et al., 2006; Preston and Nicholl, 2006; Tavalai et al., 2006; Lukashchuk et al., 2008; Adler et al., 2011; Lee et al., 2012).