Among them, 17 genes have been reported to be driver genes in HNSCC, such as ASPSCR1, BIRC3, CBFA2T3, EGFR, ERBB2, FGFR1, NFE2L2, PIK3CA, RECQL4, RNF213, and WHSC1L1 were located in copy-number gain regions, while CDKN2A, FAT1, LRP1B, PTPRD, PTEN, and RB1 were identified in copy-number loss regions. This evidence concerns the gene RNF213 and head and neck squamous cell carcinoma.