Among them, 17 genes have been reported to be driver genes in HNSCC, such as ASPSCR1, BIRC3, CBFA2T3, EGFR, ERBB2, FGFR1, NFE2L2, PIK3CA, RECQL4, RNF213, and WHSC1L1 were located in copy-number gain regions, while CDKN2A, FAT1, LRP1B, PTPRD, PTEN, and RB1 were identified in copy-number loss regions. The gene discussed is NFE2L2; the disease is head and neck squamous cell carcinoma.