Changes in ANXA1 expression are associated with specific types of tumors, and the expression of ANXA1 has been studied in a wide range of cancers: ANXA1 is upregulated in lung cancer, colorectal cancer, hepatocellular carcinoma, pancreatic cancer, multiple myeloma, and melanoma, while in other types of cancers such as esophageal squamous cell carcinoma, gastric cancer, head, and neck squamous cell carcinoma, and prostate cancer, ANXA1 is downregulated or absent (8). The gene discussed is ANXA1; the disease is plasma cell myeloma.